Nanoparticle-drug combo turns white fat to brown fat with potential to treat obesity, diabetes


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According to Medical Xpress

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Bioengineered dibenzazepine-loaded nanoparticles support rapid cellular internalization and inhibit Notch signaling in adipocytes. A study conducted by Purdue University researchers further demonstrates that browning of specific fat depots is sufficient to bring about systemic improvements in metabolism. The image illustrates inductive browning of inguinal white adipose tissue (H&E staining shown in the background) by dibenzazepine-loaded nanoparticles (five particles shown in the front). Credit: Alexander M. Gokan

In a potential breakthrough for the treatment of obesity and diabetes, Purdue University scientists have found a way to deliver a drug directly to stored white fat cells to turn them into more easily burned brown fat cells.

White adipose tissue, most associated with obesity, is a type of fat that collects in the body for long-term storage of energy. It’s possible humans evolved to store white fat to act as insulation and energy storage. However, as we have become over-fed and less active, we have less need for the energy stored in white fat and it over accumulates, leading to metabolic diseases such as diabetes and obesity. More than one-third of Americans are obese, and nearly 10 percent have diabetes, according to the Centers for Disease Control and Prevention.

Brown fat is more readily burned by the body, dissipating energy into heat. Scientists, including Purdue’s Meng Deng, assistant professor of agricultural and biological engineering, biomedical engineering and materials engineering, and Shihuan Kuang, professor of animal sciences, have been looking for ways to decrease white fat in favor of brown fat through a signaling pathway that is known to regulate cell differentiation and cell identity.

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This article and images were originally posted on [Medical Xpress] August 30, 2017 at 07:33AM

Credit to Author and Medical Xpress

 

 

 

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