Are scientists studying the wrong kind of mice?

Your daily selection of the latest science news!

According to (This article and its images were originally posted on Medical Xpress December 5, 2018 at 08:01AM.)

(Cover Image)

Credit: CC0 Public Domain

Mice represent well over half of the non-human subjects of biomedical research, and the vast majority of those mice are inbred. Formed by generation after generation of mating between brothers and sisters, inbred mice are genetically identical to each other, like twins or clones. Inbreeding is well known to reduce health and vigor across species; this biological fact is the reason that incest is a universal taboo. Although inbred mice have specific and important uses in genetics and immunology, the main reason they are preferred over more robust “outbred” mice is precisely because they don’t differ genetically. A general assumption shared among scientists is that data collected using inbred mice will feature less variability, leading to faster, cheaper, and more powerful experiments.

A new study published November 30 in Nature Methods shows that this assumption is false. Researchers at McGill University analyzed previously published scientific papers from across the biomedical literature that used both inbred and outbred in the same experiments. After comparing the variability among individual inbred and outbred mice, the team failed to find any differences across a wide range of physical and behavioral traits.

 

|
+ Got any news, tips or want to contact us directly? Feel free to email us: esistme@gmail.com.

To see more posts like these; please subscribe to our newsletter. By entering a valid email, you’ll receive top trending reports delivered to your inbox.

__

This article and images were originally posted on [Medical Xpress] December 5, 2018 at 08:01AM. Credit to the original author and Medical Xpress | ESIST.T>G>S Recommended Articles Of The Day.

 

 

 

Advertisements

Leave a Reply

This site uses Akismet to reduce spam. Learn how your comment data is processed.